Applied Extracts is a pioneer in designing and manufacturing pilot-scale Pressurized Liquid Extraction (PLE) systems for cutting-edge biotechnology and bio-process innovators. This advanced extraction method employs a carefully optimized solvent mixture—typically a combination of acid, alcohol, and water—subjected to pressures up to 2,500 psi and temperatures exceeding 180°C. Under these controlled conditions, PLE enables rapid, high-yield extraction of valuable compounds such as phenols, flavonoids, alkaloids, and lipids from a wide range of natural materials. Compared to conventional solvent extraction, PLE delivers superior efficiency, reproducibility, and environmental performance by minimizing solvent use and reducing process time.
Beyond its technological sophistication, Applied Extracts’ PLE systems are built with flexibility and scalability in mind. Each system can be customized to accommodate different solvents, feedstocks, and process conditions, allowing researchers to optimize extraction protocols for diverse applications—from botanical actives and nutraceuticals to advanced biomaterials. The modular design and robust safety features make these systems ideal for laboratory development as well as pilot-scale production, bridging the gap between research and full-scale commercialization.
In addition to equipment manufacturing, Applied Extracts provides end-to-end process development support, including solvent optimization, temperature and pressure profiling, and post-extraction purification strategies. This integrated approach helps clients accelerate their innovation pipeline, reduce R&D costs, and move more quickly from concept to market-ready product. The company’s engineering expertise and commitment to sustainability make its PLE systems a preferred choice for organizations focused on green chemistry and circular bioeconomy practices.
As industries transition toward cleaner, more efficient extraction technologies, Applied Extracts continues to lead the field with systems that combine precision engineering, environmental stewardship, and scientific excellence. Whether for producing high-purity botanical extracts, bio-based chemicals, or pharmaceutical intermediates, the company’s pilot-scale PLE platforms represent the future of scalable, sustainable extraction technology.
Our client commissioned a custom-made, 50-liter pressurized liquid extraction (PLE) machine that operated in continuous-flow mode at up to 2500 psi and 200 °C, with a flow rate of up to 1.5 L/min. The advantage of high-pressure operation is that, when pressurized, the process operating temperature can exceed the solvent’s boiling point at atmospheric pressure.
The machine operates with a proprietary mixture of solvents at low pH, in a manner similar to the Organosolv process. If you are a research group interested in a lab pilot-scale machine to further develop your bioprocess technology, contact us to discuss your project in detail!
Contact us to learn more and discuss your project in detail.
